p40、天门冬氨酸蛋白酶、甲状腺转录因子-1在肺鳞癌与腺癌表达敏感性和特异性p40、Napsin-A and TTF-1——the specific immunohistochemical mark to identify squamous cell carcinoma and adenocarcinoma of non-small cell Lung Cancer
仇加高;
摘要(Abstract)：
目的:探讨肺非小细胞癌组织中鉴别鳞癌和腺癌有意义的免疫组化检测标记。方法:采用免疫组织化学SP法检测非小细胞肺癌51例组织中p63、p40、CK5/6、甲状腺转录因子-1(TTF-1)、CK7、天门冬氨酸蛋白酶(Napsin-A)的表达。结果:(1)p40、p63、CK5/6在非小细胞肺癌中表达:非小细胞肺癌51例中,p40、p63、CK5/6在鳞状细胞癌20例中阳性表达为20例(100.0%),19例(95.0%),18例(90.0%),在腺癌31例组织中阳性表达为0例(0.0%)、6例(19.4%)、3例(9.7%)。p40在31例腺癌中无1例表达,特异性高于p63、CK5/6(χ2=6.424,P<0.05),而p63、CK5/6两组间特异性比较差异无统计学意义。(2)TTF-1、CK7、Napsin-A在非小细胞肺癌中表达:非小细胞肺癌51例中,TTF-1、CK7、Napsin-A在肺腺癌31例中阳性为27例(87.1%)、25例(80.6%)、28例(90.3%),在鳞状细胞癌20例组织中阳性表达分别为1例(5.0%)、7例(35.0%)、0例(0.0%),TTF-1和Napsin-A阳性表达特异性高于CK7(χ2=12.197,P<0.01)。结论:p40、NapsinA、TTF-1联合检测可更好地鉴别诊断肺非小细胞癌,为临床进行靶向治疗提供依据。
关键词(KeyWords)： 肺非小细胞癌;免疫组织化学SP法;p40;天门冬氨酸蛋白酶;甲状腺转录因子-1
基金项目(Foundation):
作者(Authors): 仇加高;
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