nav emailalert searchbtn searchbox tablepage yinyongbenwen piczone journalimg journalInfo journalinfonormal searchdiv searchzone qikanlogo popupnotification paper paperNew
2026, 02, v.40 140-144
circRNA在原发性肝细胞癌中的研究进展及临床应用
基金项目(Foundation): 南通市科技计划项目(MS22020014)
邮箱(Email): Shaojianguo4144@163.com;
DOI: 10.19767/j.cnki.32-1412.2026.02.005
发布时间: 2026-04-20
出版时间: 2026-04-20
移动端阅读
摘要:

近年来环状RNA(circRNA)由于其独特的结构和功能逐渐引起医学研究者的关注。转录组学技术快速发展使得circRNA研究进入新阶段。原发性肝细胞癌(hepatocellular carcinoma,HCC)具有高度侵袭性,发病率和死亡率较高,当前对HCC的诊断和治疗手段仍存在诸多局限。本文系统综述circRNA基本生物学特征、转录组学技术在HCC中的研究、circRNA在HCC中的作用及其临床应用,探讨circRNA作为生物标志物和治疗靶点的应用前景,以期为HCC的早期诊断和精准治疗提供新的思路和方向。

Abstract:

KeyWords:
参考文献

[1]HU X,CHEN G R,HUANG Y C,et al. Integrated multiomics reveals silencing of has_circ_0006646 promotes TRIM21-mediated NCL ubiquitination to inhibit hepatocellular carcinoma metastasis[J]. Adv Sci(Weinh),2024,11(16):e2306915.

[2]ZHANG P,SUN H,WEN P,et al. circRNA circMED27 acts as a prognostic factor and mediator to promote lenvatinib resistance of hepatocellular carcinoma[J]. Mol Ther Nucleic Acids,2022,27:293-303.

[3]LAN S Q,ZHONG G Q. Identification of a novel survival and immune microenvironment related CeRNA regulatory network for hepatocellular carcinoma based on circHECTD1[J]. Heliyon,2024,10(13):e33763.

[4]XU Q,CHEN S,HU Y,et al. Prognostic Role of ceRNA Network in Immune Infiltration of Hepatocellular Carcinoma[J]. Front Genet,2021,12:739975.

[5]XU H Z,LIN X Y,XU Y X,et al. An emerging research:the role of hepatocellular carcinoma-derived exosomal circRNAs in the immune microenvironment[J]. Front Immunol,2023,14:1227150.

[6]JIANG Y,QI S,ZHANG R,et al. Diagnosis of hepatocellular carcinoma using liquid biopsy-based biomarkers:a systematic review and network meta-analysis[J]. Front Oncol,2024,14:1483521.

[7]MENG H,NIU R,HUANG C,et al. Circular RNA as a novel biomarker and therapeutic target for HCC[J]. Cells,2022,11(12):1948.

[8]DAWOUD A,ELMASRI R A,MOHAMED A H,et al. Involvement of CircRNAs in regulating the“new generation of cancer hallmarks”:a special depiction on hepatocellular carcinoma[J]. Crit Rev Oncol,2024,196:104312.

[9]SHEN H,LIU B Q,XU J J,et al. Circular RNAs:characteristics,biogenesis,mechanisms and functions in liver cancer[J]. J Hematol Oncol,2021,14(1):134.

[10]TANG C,HE X,JIA L,et al. Circular RNAs in glioma:Molecular functions and pathological implications[J]. Noncoding RNA Res,2024,9(1):105-115.

[11]WANG P,ZHANG Y,DENG L,et al. The function and regulation network mechanism of circRNA in liver diseases[J]. Cancer Cell Int,2022,22(1):141.

[12]QIN S,MAO Y,CHEN X,et al. The functional roles,crosstalk and clinical implications of m6A modification and circRNA in hepatocellular carcinoma[J]. Int J Biol Sci,2021,17(12):3059-3079.

[13]IMANISHI S,NAGATA S,FUJITA T,et al. Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated,respectively,in hepatocellular carcinoma[J]. Int J Exp Pathol,2022,103(6):245-251.

[14]GAO P,YANG Y,LI X W,et al. Circular RNA hsa_circ_0098181 inhibits metastasis in hepatocellular carcinoma by activating the Hippo signaling pathway via interaction with eEF2[J]. Ann Hepatol,2023,28(5):101124.

[15]CHEN Y H,LING Z N,CAI X L,et al. Activation of YAP1by N6-methyladenosine-modified circCPSF6 drives malignancy in hepatocellular carcinoma[J]. Cancer Res,2022,82(4):599-614.

[16]LU J,RU J,CHEN Y,et al. N6-methyladenosine-modified circSTX6 promotes hepatocellular carcinoma progression by regulating the HNRNPD/ATF3 axis and encoding a 144aminoacid polypeptide[J]. Clin Transl Med,2023,13(10):e1451.

[17]ZHANG H,PEI S,LI J,et al. Insights about exosomal circular RNAs as novel biomarkers and therapeutic targets for hepatocellular carcinoma[J]. Front Pharmacol,2024,15:1466424.

[18]HUANG X Y,HUANG Z L,HUANG J,et al. Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis[J]. J Exp Clin Cancer Res,2020,39(1):20.

[19]HU Z Q,CHEN G,ZHAO Y P,et al. Exosome-derived circCCAR1 promotes CD8+T-cell dysfunction and anti-PD1resistance in hepatocellular carcinoma[J]. Mol Cancer ,2023,22(1):55.

[20]WANG X,DONG F L,WANG Y Q,et al. Exosomal circTGFBR2 promotes hepatocellular carcinoma progression viaenhancing ATG5 mediated protective autophagy[J]. Cell Death Dis,2023,14(7):451.

[21]MO M L,LIU B H,LUO Y H,et al. Construction and comprehensive analysis of a circRNA-miRNA-mRNA regulatory network to reveal the pathogenesis of hepatocellular carcinoma[J]. Front Mol Biosci,2022,9:801478.

[22]XU J J,JI L,LIANG Y L,et al. CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1[J]. Signal Transduct Target Ther,2020,5(1):298.

[23]ZHAI Z S,LI H Y. Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma(HCC)pathogenesis[J]. Clin Exp Med,2025,25(1):60.

[24]LOUIS C,LECLERC D,COULOUARN C. Emerging roles of circular RNAs in liver cancer[J]. JHEP Rep,2022,4(2):100413.

[25]LIU Y,DONG G,YU J,et al. Integration of single-cell and spatial transcriptomics reveals fibroblast subtypes in hepatocellular carcinoma:spatial distribution,differentiation trajectories,and therapeutic potential[J]. J Transl Med,2025,23(1):198.

[26]CUI J,ZENG F,TANG M,et al. Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma[J]. Front Cell Dev Biol,2025,13:1449624.

[27]LIU Y,DONG Z,CHEN W,et al. Construction of a ceRNA regulatory network to explore potential pathogenesis mechanisms involved in human hepatocellular carcinoma[J]. Sci Rep,2023,13(1):22058.

[28]LI L,LI G,ZHAI W. Single-cell transcript omic analysis reveals efferocytosis signature predicting immunotherapy response in hepatocellular carcinoma[J]. Dig Liver Dis,2025,57(5):611-623.

[29]CHEN X T,WU S J,HE H X,et al. G2M-checkpoint related immune barrier structure and signature for prognosis and immunotherapy response in hepatocellular carcinoma:insights from spatial transcriptome and machine learning[J].J Transl Med,2025,23(1):202.

[30]ZHANG Y,WANG Y. Circular RNAs in hepatocellular carcinoma:emerging functions to clinical significances[J].Front Oncol,2021,11:667428.

[31]ZHANG H Y,ZHU J J,LIU Z M,et al. Aprognostic fourgene signature and a therapeutic strategy for hepatocellular carcinoma:Construction and analysis of a circRNA-mediated competing endogenous RNA network[J]. Hepatobiliary Pancreat DisInt,2024,23(3):272-287.

[32]XU F,JIANG L Y,ZHAO Q W,et al. Whole-transcriptome and proteome analyses identify key differentially expressed mRNAs,miRNAs,lncRNAs and circRNAs associated with HCC[J]. Oncogene,2021,40(29):4820-4831.

[33]SU H H,ZHOU X W,LIN G C,et al. Deciphering the oncogenic landscape of hepatocytes through integrated singlenucleus and bulk RNA-seq of hepatocellular carcinoma[J].Adv Sci,2025,12(14):2412944.

[34]WANG X X,SHENG W,XU T,et al. CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARα/CCL2pathway[J]. Aging(Albany NY),2021,13(8):11969-11987.

[35]XU T,WANG L,JIA P,et al. An integrative transcriptomic and methylation approach for identifying differentially expressed circular RNAs associated with DNA methylation change[J]. Biomedicines,2021,9(6):657.

[36]DU A S,LI S Q,ZHOU Y Z,et al. M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma[J]. Mol Cancer,2022,21(1):109.

[37]LI Y X,JI M Y,HUANG X,et al. CircRNA_0040705 promotes the progression of hepatocellular carcinoma[J]. IUBMB Life,2022,74(5):408-418.

[38]DU W,LI Y,WANG X,et al. Circular RNA circESYT2serves as a microRNA-665 sponge to promote the progression of hepatocellular carcinoma through ENO2[J]. Cancer Sci,2024,115(8):2659-2672.

[39]XU J,WAN Z,TANG M,et al. N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling[J].Mol Cancer,2020,19(1):163.

[40]GONG J,HAN G,CHEN Z,et al. CircDCAF8 promotes the progression of hepatocellular carcinoma through miR-217/NAP1L1 axis,and induces angiogenesis and regorafenib resistance viaexosome-mediated transfer[J]. J Transl Med,2024,22(1):517.

[41]TRETTI PARENZAN C,MOLIN A D,LONGO G,et al.Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A:AFF1 fusion[J].Blood Adv,2024,8(5):1305-1319.

[42]ABAZA T,EL-AZIZ M K A,DANIEL K A,et al. Emerging role of circular RNAs in hepatocellular carcinoma immunotherapy[J]. Int J Mol Sci,2023,24(22):16484.

[43]AFRA F,ALI MAHBOOBIPOUR A,SALEHI FARID A,et al. Recent progress in the immunotherapy of hepatocellular carcinoma:non-coding RNA-based immunotherapy may improve the outcome[J]. Biomed Pharmacother,2023,165:115104.

[44]DUAN S,WANG S,HUANG T,et al. circRNAs:insight into their role in tumor-associated macrophages[J]. Front Oncol,2021,11:780744.

[45]WANG D L,LI R,JIANG J J,et al. Exosomal circRNAs:novel biomarkers and therapeutic targets for gastrointestinal tumors[J]. Biomed Pharmacother,2023,157:114053.

[46]YAN K,CHENG W,XU X,et al. Circulating RNAs,circ_4911 and circ_4302,are novel regulators of endothelial cell function under a hepatocellular carcinoma microenvironment[J]. Oncol Rep,2020,44(4):1727-1735.

[47]HAN T,CHEN L,LI K,et al. Significant CircRNAs in liver cancer stem cell exosomes:mediator of malignant propagation in liver cancer[J]. Mol Cancer,2023,22(1):197.

[48]LI Y,LI R H,CHENG D,et al. The potential of CircRNA1002 as a biomarker in hepatitis B virus-related hepatocellular carcinoma[J]. Peer J,2022,10:e13640.

[49]SONG R,MA S,XU J,et al. A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR[J]. Mol Cancer,2023,22(1):16.

[50]GUO S,HU C,ZHAI X,et al. Circular RNA 0006602 in plasma exosomes:a new potential diagnostic biomarker for hepatocellular carcinoma[J]. Am J Transl Res,2021,13(6):6001-6015.

[51]KANG M K,KIM G,PARK J G,et al. Tissue circular RNA_0004018 and 0003570 as novel prognostic biomarkers for hepatitis B-related hepatocellular carcinoma[J].Genes(Basel),2023,14(10):1963.

[52]TANG L,JI Y,NI C Y,et al. EIF4A3-mediated biogenesis of CircFADS1 promotes the progression of hepatocellular carcinoma via Wnt/β-catenin pathway[J]. Adv Sci,2025,12(14):2411869.

基本信息:

DOI:10.19767/j.cnki.32-1412.2026.02.005

中图分类号:R735.7

引用信息:

[1]黄新雨,邵建国.circRNA在原发性肝细胞癌中的研究进展及临床应用[J].交通医学,2026,40(02):140-144.DOI:10.19767/j.cnki.32-1412.2026.02.005.

基金信息:

南通市科技计划项目(MS22020014)

发布时间:

2026-04-20

出版时间:

2026-04-20

引用

GB/T 7714-2015 格式引文
MLA格式引文
APA格式引文