| 541 | 18 | 40 |
| 下载次数 | 被引频次 | 阅读次数 |
<正>炎症性肠病(Inflammatory bowel disease,IBD)包括溃疡性结肠炎(Ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD),是一种自身免疫性疾病,其发病机制尚不清楚。近年来人们逐渐接受"免疫耐
Abstract:[1]Kidd M,Gustafsson BI,Drozdov I,et al.IL1beta-and LPS-induced serotonin secretion is increased in EC cells derived from Crohn's disease[J].Neurogastroenterol Motil,2009,21(4):439-450.
[2]Van Assche G,Dalle I,Noman M,et al.A pilot study on the use of the humanized anti-interleukin-2 receptor antibody daclizumab in active ulcerative colitis[J].Gastroenterol,2003,98(2):369-376.
[3]Aleksandra Nielsen A,Nederby Nielsen J,Schmedes A,et al.Saliva Interleukin-6in patients with inflammatory bowel disease[J].Scand Gastroenterol,2005,40(12):1444-1448.
[4]Ito H,Takazoe M,Fukuda Y,et al.A pilot randomized trial of a human anti-interleukin-6receptor monoclonal antibody in active Crohn's disease[J].Gastroenterology,2004,126(4):989-996.
[5]Hechtman DH,Cybulsky MI.Intravascular IL-8.Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation[J].J Immunol,1991,147(3):883-892.
[6]程留芳.消化系统疾病病例分析[M].北京:科学出版社,2003.67-68.
[7]Micallef MJ,Tanimoto T,Kohno K,et al.Interleukin18in-duces a synergistic enhancement of interferon gamma pro-duction in mixed murine spleen cell-tumor cell cultures:role of endogenous interleukin 12[J].Cancer Detect Prev,2000,24(3):234-243.
[8]Marmon PJ,Fuss IJ,Mayer L,et al.Anti-interleukin-12an-tibody for acute Crohn’s disease[J].N Eng J Med,2004,351(20):2069-2079.
[9]Moseley TA,Hawdenschild DR,Rose L,et al.Interleukin-17family and IL-17receptors[J].Cytokine Growth Factor Rev,2003,14(2):155-174.
[10]Witowski J,Ksiazek K.Interleukin-17:a mediator of inflam-matory responses[J].Cell Mol Life Sci,2004,61(5):567.
[11]Langrish CL,Chen Y,Blumenschein WM,et al.IL-23 drives a pathogenic T cell population that induces autoim-mune inflammation[J].J Exp Med,2005,201(2):233-240.
[12]Park H,L Z,Yang XO,et al.A distinct lineage of CD4T cells regulates tissue inflammation by producing interleukin17[J].Nat Immunol,2005,6(11):1133-1141.
[13]Ruddy MJ,W G,Liu XK,et al.Functional cooperation be-tween interleukin-17 and tumor necrosis factor-alpha is mediated by CCAAT/enhancer-binding protein family mem-bers[J].J Biol Chem,2004,279(4):2559-2567.
[14]Fujino S,Andoh A,Bamba S,et al.Increased expression of interleukin17in inflammatory bowel disease[J].Gut,2003,52(1):65-70.
[15]Yang L,Anderson DE,Baecher-Allan C,et al.IL-21 and TGF-beta are required for differentiation of human T(H)17cells[J].Nature,2008,454(7202):350-352.
[16]HlttV,Klemetti P,Sipponen T,et al.IL-23/IL-17 im-munity as a hallmark of Crohn's disease[J].Inflammatory Bowel Diseases,2008,14(9):1175-1184.
[17]Nakanishi K,Yoshimoto T,Tsutsui H,et al.Interleukin-18 regulates both Th1and Th2responses[J].Annu Rev Im-munol,2001,19:423-474.
[18]Schmidt C,Giese T,Goebel R,et al.Interleukin-18 is in-creased only in a minority of patients with active Crohn’s disease[J].Int J Colorectal Dis,2007,22(9):1013-1020.
[19]张炳勇,吕愈敏,洪天配,等.炎症性肠病患者肠黏膜白细胞介素18的表达及意义[J].北京大学学报(医学版),2003,35(2):150-153.
[20]Maerten P,Shen C,Colpaert S,et al.Involvement of inter-leukin18 in Crohn's disease:evidence from in vitro analy-sis of human gut inflammatory cells and from experimental colitis models[J].Clin Exp Immunol,2004,135(2):310-317.
[21]刘占举,吴国华,张炳勇,等.IL-18对炎症性肠病患者外周血和肠黏膜固有层淋巴细胞增殖和炎症介质分泌的影响[J].郑州大学学报(医学版),2006,41(5):828-830.
[22]Kallel L,Boubaker J,Louzir H,et al.Colonic expression of gamma-interferon and interleukin-10 in Crohn's disease and ulcerative colitis[J].Presse Med,2005,34(1):8-12.
[23]Iijima H,Takahashi I,Kishi D,et al.Alteration of inter-leukin4production results in the inhibition of T helper type 2 cell-dominated inflammatory bowel disease in T cell receptor alpha chain-deficient mice[J].J Exp Med,1999,190(5):607-615.
[24]Erdman SE,Rao VP.CD4(+)CD25(+)regulatory lympho-cytes require interleukin 10 to interrupt colon carcinogene-sis in mice[J].Cancer Res,2003,63(18):6042-6050.
[25]Ebert EC,Panja A,Das KM,et al.Patients with inflamma-tory bowel disease may have a transforming growth factor-beta-,interleukin(IL)-2-or IL-10-deficient state induced by intrinsic neutralizing antibodies[J].Clin Exp Immunol,2009,155(1):65-71.
[26]Fichtner-Feigl S,Fuss IJ,Young CA,et al.Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitis[J].J Im-munol,2007,178(9):5859-5870.
[27]Boirivant M,Pallone F,Di Giacinto C,et al.Inhibition of Smad7 with a specific antisense oligonucleotide facilitates TGF-beta1-mediated suppression of colitis[J].Gastroen-terology,2006,131(6):1786-1798.
基本信息:
中图分类号:R574.62
引用信息:
[1]施颖琦.细胞因子在炎症性肠病免疫调节中的研究进展[J].交通医学,2009,23(03):310-313.
2009-06-20
2009-06-20